Inhibiting the Interleukin-11 Gene – The Key to Anti-aging!

 

In a discovery published in Nature, a team of scientists from Duke-NUS Medical School in Singapore may have found a key to slow aging. The team demonstrated in preclinical models that the protein interleukin-11 (IL-11) actively promotes aging and that removing the IL-11 gene or using an anti-IL-11 antibody dramatically increases the lifespan and health of aging mice. These findings suggest that anti-IL-11 treatments could combat age-related diseases with minimal side effects, offering a promising avenue for future human trials.

IL-11 leads to fat accumulation and muscle mass loss, two key hallmarks of aging. This protein has also been linked to several other aging-related problems. It was inherited from fish species approximately 450 million years ago. Chronic inflammation, tissue scarring, metabolic diseases, loss of muscular mass, and cardiac issues are all linked to IL-11.

 

In preclinical studies, the team found that with age, organs expressed increasing levels of the IL-11 protein, which, in turn, promoted fat accumulation in the liver and abdomen, and reduced muscle mass and strength—two conditions that are hallmarks of human aging.

According to the team, these results are the first in the world to demonstrate that IL-11 is a principal factor in aging.

In further experiments, animals treated with the anti-IL-11 therapy were less likely to develop cancer: less than 16 per cent of the treated rodents had tumours, compared with more than 60 per cent of those in the control group.

However, we won’t know if the same is true in people until clinical trials are conducted, says Stuart Cook at Duke-NUS Medical School in Singapore. Multiple trials are under way to test anti-IL-11 therapies in people with certain inflammatory conditions, such as pulmonary fibrosis, but none is investigating its potential anti-aging effects, he says.

Regenerative and Repair Mechanisms Including the Inhibition of IL-11

The number of studies and interventions have highlighted several phytochemicals, and nutrients, that might target inhibition of IL-11, including increased dietary intake or supplementation with lutein and other carotenoids, curcumin/turmeric, quercetin, osthole/coumarin, allicin, β-elemene, rosmarinic acid, and omega-3 fatty acids.

IL-11 Antibodies

Antibodies that detect IL-11 can be used in several scientific applications, including Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry and Neutralization. These antibodies target IL-11 in Human, Mouse and Rat samples. You can get more information on these antibodies here: https://www.thermofisher.com/antibody/product/IL-11-Antibody-Polyclonal/PA5-95982

 

Sources:

1.       https://www.nature.com/articles/s41586-024-07701-9

 

2.       https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-il-11-monoclonal-antibody-9mw3811

 

3.       https://news.nutrilink.co.uk/2024/07/24/inhibit-il-11-and-live-longer/

 


 

 

 


Comments

Post a Comment

Popular posts from this blog

How You can Earn by Becoming an Amazon Associate

If you are interested in Promoting health supplements and any other product linked to healthy living, exercise, why not join as Amazon Associates ? You don't need to have a website or blog, you can promote your links associated your Amazon Associates account through your Facebook and Instagram account, and you will earn commission on every sale that you make through your banners and links. Of course, you, your family members or friends cannot click on the links/banner and buy an Amazon product, because such clicks will not qualify for commission. You can become an Amazon Associate by simply clicking this link: Amazon Associates .
Read more

Biohacking Supplements for Longevity and Wellness

The objective of hacking your biology, biohacking is to maximize your health and healthy aging. That means enhancing the body's capacity to withstand stress and immune challenges, while expanding upon its ability to maintain energetic function and synthesis function of hormones, proteins, neurotransmitters, and other compounds.   Key Aspects of Biohacking ·           Self-Experimentation: Biohackers explore their bodies and minds through self-experimentation, often using tools like wearable devices, blood tests, and other monitoring methods to gather data.   ·           Nutrition Optimization: Personalized nutrition plans, specialized diets, and dietary supplements are commonly employed to achieve health and performance goals.   ·           Exercise Optimization: Tailoring exercise routines to individual needs, such as high-intensity inter...
Read more

Nutrients that Prevent Telomere Shortening

Image
Telomerase is an enzyme that helps maintain telomeres , the protective tips of chromosomes. As we age, our telomeres naturally shorten, contributing to the aging process. Telomerase supplements are designed to promote the lengthening of telomeres, which may help prevent some age-related diseases and improve overall health. What are telomeres?  Telomeres are stretches of DNA at the end of chromosomes that protect the end from deterioration. They shorten each time a cell divides, and when they get too short, cells can no longer divide and die off or become cancerous. Telomere length is a good biological marker of aging, and shorter telomeres usually indicate greater age and a higher likelihood of age-related pathologies. As telomeres provide protection for the genetic material inside DNA, shorter telomeres provide less protection. The shorter the telomere, the more likely a subject is to suffer from disease or age-related illnesses.  What is telomerase?  Telomerase ...
Read more