Health Benefits of Calcium Dobesilate for Senior Citizens

 

What is Calcium dobesilate?

Calcium, we all know, is essential for strong bones. But calcium dobesilate, a calcium salt of dobesilic acid, is a different thing altogether. This medication acts like a traffic coordinator for your blood cells, particularly in the veins. By improving their flexibility and reducing clumping, calcium dobesilate helps blood flow smoothly, preventing unwanted traffic jams.

 Classified as a vasoprotective agent, it has gained recognition for its potential to improve blood vessel health. Calcium Dobesilate is a medication used to treat hemorrhoids (piles) and varicose veins. Calcium Dobesilate works by reducing capillary leakage, thickening blood, and enhancing fluid removal through the lymphatic system.

 Calcium Dobesilate Health Benefits:

Calcium dobesilate is commonly prescribed to treat conditions related to weak or damaged blood vessels, including:

Diabetic retinopathy

Diabetic retinopathy, a microvascular complication of diabetes, disrupts the blood-retinal barrier leading to leakage and haemorrhage within the retina. Calcium dobesilate, with its potential to improve vascular health by reducing capillary fragility and permeability, has emerged as a therapeutic candidate for this condition. It effectively relieves haemorrhoid symptoms by reducing inflammation, improving blood circulation, and promoting healing in the affected area.

                                          

      Varicose veins:

Calcium dobesilate has demonstrated superior efficacy compared to placebo in alleviating certain chronic venous insufficiency (CVI) symptoms, with more pronounced benefits observed in patients with severe CVI. Calcium dobesilate has emerged as a potential therapeutic agent for CVI, with studies suggesting its ability to improve blood flow and reduce leakage from weakened vessels.

 

Hemorrhoids (piles):

 Internal haemorrhoids, characterized by dilated veins in the anal canal and rectum, can cause significant discomfort. Calcium Dobesilate effectively relieves symptoms of haemorrhoids by reducing inflammation, improving blood circulation, and promoting healing in the affected area. Calcium dobesilate helps strengthen blood vessels, reducing fluid leakage and swelling in tissues. The use of calcium dobesilate for piles & fistula is being explored as a potential treatment to improve symptoms and promote healing.


Mechanism of Action

 

Reduced Capillary Permeability:

The primary mechanism of action for calcium dobesilate is believed to be its effect on capillary wall structure, particularly the basement membrane. This scaffold-like layer provides crucial support and stability to blood vessels. Calcium dobesilate appears to interact with the basement membrane in two ways:

 

·         Stabilization of collagen chains:

Collagen is a major structural component of the basement membrane. By stabilizing these collagen chains, calcium dobesilate may reinforce the overall integrity of the capillary wall.

 

·         Interaction with biochemical mediators:

These molecules regulate capillary permeability, influencing how much fluid leaks out of the vessels. Calcium dobesilate might influence the activity of these mediators, leading to a reduction in leakage.

 

Improved Blood Flow:

·         Reduced Blood Viscosity:

While not a true blood thinner, calcium dobesilate may slightly decrease whole blood viscosity, particularly at low shear rates relevant to venous flow. This could improve blood flow within hemorrhoidal veins.

 

·         Enhanced Nitric Oxide Production:

Recent research suggests calcium dobesilate might stimulate the production of nitric oxide (NO) in the endothelium, the inner lining of blood vessels. NO acts as a vasodilator, promoting relaxation of blood vessel walls and potentially improving circulation in hemorrhoidal tissue.

 

Possible Anti-inflammatory Effects:

Emerging evidence suggests calcium dobesilate possesses anti-inflammatory properties, potentially offering therapeutic benefits in chronic venous insufficiency (CVI) and hemorrhoids.

 

Calcium Dobesilate and Diabetic Erectile Dysfunction:

Results suggest that dobesilate may be of help to treat diabetic erectile dysfunction. Co-administration with phosphodiesterase (PDE 5) inhibitors warrants further investigation. The relaxation of arterial and trabecular penile smooth muscle is needed to achieve and maintain penile erection.

 

Calcium Dobesilate and Micro-vascular Diseases:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement leads to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate, due to its vasoactive and angio-protective properties, has shown a unique, multitarget mode of action in several experimental studies and in different animal models, for the treatment of diabetic microvascular complications.

 

Disclaimer: The above article is for information purpose only. Calcium dobesilate is a prescription medicine, that can only be made available to a patient on the written instruction of an authorised health professional. Do not try to self-medicate yourselves with these.

 Sources:

https://www.sciencedirect.com/science/article/pii/S0024320519301134

https://www.wbcil.com/blog/

 

 

 

 

 


Comments

Post a Comment

Popular posts from this blog

How You can Earn by Becoming an Amazon Associate

If you are interested in Promoting health supplements and any other product linked to healthy living, exercise, why not join as Amazon Associates ? You don't need to have a website or blog, you can promote your links associated your Amazon Associates account through your Facebook and Instagram account, and you will earn commission on every sale that you make through your banners and links. Of course, you, your family members or friends cannot click on the links/banner and buy an Amazon product, because such clicks will not qualify for commission. You can become an Amazon Associate by simply clicking this link: Amazon Associates .
Read more

Six Key Food Groups that Are Healthy for Your Heart

Researchers investigated the impact of different food groups on cardiovascular health. They found that diets rich in fruits, vegetables, legumes, nuts, whole-fat dairy, and fish were linked to lower cardiovascular risk. Further studies are needed to understand how much each component contributes to overall risk reduction. Unhealthy diets are a major risk factor for cardiovascular disease (CVD). In particular, higher amounts of processed meats, refined grains, and sugar-sweetened beverages are known to increase cardiovascular risk.  Concurrently, diets such as the Dietary Approaches to Stop Hypertension (DASH) diet, Mediterranean and Healthy Eating Index (HEI) are linked to lower CVD risk. These diets all include increased consumption of: Fruit Vegetables Legumes Nuts Fish However, recent studies, have shown that some foods—such as whole-fat dairy—previously thought to increase CVD risk may have neutral or beneficial effects. However, many of these new findings have yet to be incor...
Read more

Nutrients that Prevent Telomere Shortening

Image
Telomerase is an enzyme that helps maintain telomeres , the protective tips of chromosomes. As we age, our telomeres naturally shorten, contributing to the aging process. Telomerase supplements are designed to promote the lengthening of telomeres, which may help prevent some age-related diseases and improve overall health. What are telomeres?  Telomeres are stretches of DNA at the end of chromosomes that protect the end from deterioration. They shorten each time a cell divides, and when they get too short, cells can no longer divide and die off or become cancerous. Telomere length is a good biological marker of aging, and shorter telomeres usually indicate greater age and a higher likelihood of age-related pathologies. As telomeres provide protection for the genetic material inside DNA, shorter telomeres provide less protection. The shorter the telomere, the more likely a subject is to suffer from disease or age-related illnesses.  What is telomerase?  Telomerase ...
Read more