Pyridostigmine and Human Growth Hormone (HGH)

Pyridostigmine, classified as a type of parasympathomimetic (acetylcholinesterase inhibitor,), is used to treat muscle weakness in people with myasthenia gravis or forms of congenital myasthenic syndrome and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations. It is used to treat underactive bladder. It is sometimes also used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy. It is also being prescribed 'off-label' for postural orthostatic tachycardia syndrome. 

Human Growth Hormone (HGH) or somatotropin, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development. GH also stimulates production of Insulin-like growth factor 1 (IGF-1) and increases the concentration of glucose and free fatty acids.

Pyridostigmine (PD) and Human Growth Hormone (HGH)

Previous studies have shown that pyridostigmine (PD) is capable of increasing the growth hormone (GH) response to GH-releasing hormone (GHRH) in young healthy subjects. Recent studies have shown that PD significantly potentiated GH responses to GHRH not only in young men, but also elderly men and postmenopausal women; but not in young women.

Mechanism of Action

Pyridostigmine has been found to potentiate GH-releasing hormone (GHRH)-induced GH release. It selectively amplifies the mass of GH secreted per burst without altering GH burst frequency or basal GH secretion. The mechanism involves stimulating GH secretory burst amplitude (maximal rate of GH secretion within the release episode) without prolonging burst duration.

Side effects of Pyridostigmine

Common Side Effects: These include nausea, diarrhea, frequent urination, and abdominal pain.

More Severe Side Effects: While less common, these can include low blood pressure, weakness, and allergic reactions.

Caution: Pyridostigmine is a prescription drug and can only be obtained by a prescription from your doctor.

Disclaimer: This article is for informational purposes only. It is not a substitute for professional advice, diagnosis or treatment.

Sources:

1. https://pubmed.ncbi.nlm.nih.gov/19215369/

2. https://pubmed.ncbi.nlm.nih.gov/9368506/

3. https://karger.com/nen/article-abstract/56/2/208/223856/Effects-of-Sex-and-Age-on-Pyridostigmine

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