Health Benefits of Glutathione

Glutathione is a substance made from the amino acids glycine, cysteine, and glutamic acid. It is produced by the liver and involved in many body processes. Glutathione is involved in tissue building and repair, making chemicals and proteins needed in the body, and in immune system function.

Glutathione has many important functions, including:

  • Making DNA, the building blocks of proteins and cells
  • Supporting immune function
  • Forming sperm cells
  • Breaking down some free radicals
  • Regenerating vitamins C and E
  • Transporting mercury out of the brain
  • Helping the liver and gallbladder deal with fats
  • Assisting regular cell death (a process known as apoptosis)
Glutathione and Liver Health: 

Cell death in the liver may be exacerbated by a deficiency in antioxidants, including glutathione. This can lead to fatty liver disease in both those who misuse alcohol and those who don’t. Glutathione has been shown to improve protein, enzyme, and bilirubin levels in the blood of individuals with alcoholic and nonalcoholic chronic fatty liver disease.

A study reported that glutathione was most effective when given to people with fatty liver disease intravenously, in high doses. Participants in the study also showed reductions in malondialdehyde, a marker of cell damage in the liver.

Another small study found that orally administered glutathione had positive effects on people with nonalcoholic fatty liver disease following proactive lifestyle changes. In this study, glutathione was provided in supplement form in a dose of 300 milligrams per day for four months.

Glutathione for those at Risk for Type II Diabetes:

As people age, they produce less glutathione. Researchers at Baylor School of Medicine used a combination of animal and human studies to explore the role of glutathione in weight management and insulin resistance (insulin resistance increases your risk of developing type II diabetes) in older individuals. Study findings have indicated that low glutathione levels were associated with less fat burning and higher rates of fat storing in the body.

Glutathione for those Suffering from Peripheral Arterial Disease (PAD):

Peripheral artery disease occurs when the peripheral arteries become clogged by plaque. It most commonly happens in the legs. One study reported that glutathione improved circulation, increasing the ability of study participants to walk pain-free for longer distances.

Glutathione May Help Fight against Autoimmune Disease:

The chronic inflammation caused by autoimmune diseases can increase oxidative stress. These diseases include rheumatoid arthritis, celiac disease, and lupus. According to one study, glutathione helps reduce oxidative stress by either stimulating or reducing the body’s immunological response.


Supplements that activate the natural glutathione production in the body include:

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